Soluble Antigens of Mycelia and Spherules in the In Vitro Detection of Immunity to Coccidioides immitis-Reference-Cited by-同舟云学术

Soluble Antigens of Mycelia and Spherules in the In Vitro Detection of Immunity to Coccidioides immitis

Published:1974-10 Issue:4 Volume:10 Page:700-704
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Deresinski Stanley C.¹²³,Levine H. B.¹²³,Stevens David A.¹²³

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128

2. Department of Medicine, Stanford University, Stanford, California 94305

3. Medical Microbiology Department, Naval Biomedical Research Laboratory, School of Public Health, University of California, Berkeley, California 94720

Abstract

The effect of a Coccidioides immitis spherule-derived antigen (spherulin) upon in vitro thymidine uptake by sensitized and nonsensitized lymphocytes was studied, and optimal conditions for the assay were determined. The mitogenic portion of the antigen was shown to be nondialyzable, as was true for a mycelial-derived antigen (coccidioidin). Concentrations of 20 μg of nondialyzable spherulin solids and 17 μg of nondialyzable coccidioidin solids per ml of culture were shown to be suitable for differentiating skin test-positive from skin test-negative individuals. Comparison with mycelial filtrate suggested spherulin may be a more potent mitogen for sensitized lymphocytes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.10.4.700-704.1974

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