Failure of Endotoxin to Protect C3H/HeJ Mice Against Lethal X-Irradiation

Author:

Urbaschek Renate1,Mergenhagen Stephan E.2,Urbaschek Bernhard1

Affiliation:

1. Department of Immunology and Serology, Institute of Hygiene and Medical Microbiology, Universïty of Heidelberg, D-68 Mannheim, D6, 5, West Germany

2. Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

Abstract

C3H/HeJ mice are more sensitive to lethal X-irradiation and cannot be protected by pretreatment with endotoxin, compared to the C3HeB/FeJ strain. Lack of a granulopoietic response in C3H/HeJ mice is evident.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference13 articles.

1. Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cells;Apte R. N.;J. Cell Physiol.,1976

2. Effect of endotoxin and post endotoxin plasma on in vitro granulopoiesis;Chervenick P. A.;J. Lab. Clin. Med.,1972

3. In vitro production of colony-stimulating activity. I. Exposure of mouse peritoneal cells to endotoxin;Eaves A. C.;Cell Tissue Kinet.,1974

4. Acute antigen-induced elevation of serum colony stimulating factor (CSF) levels;Metcalf D.;Immunology,1971

5. Effect of endotoxin on granulopoiesis and colony-stimulating factor;Quesenberry P.;N. Engl. J. Med.,1972

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