Affiliation:
1. Department of Pathobiology, University of Washington, Seattle 98195.
Abstract
The susceptibilities of human mycoplasmas to OPC 17116 (Otsuka America Pharmaceutical, Inc., Rockville, Md.) and temafloxacin (Abbott Laboratories, Chicago, Ill.) were determined by the agar dilution method and were compared with those to sparfloxacin and ofloxacin. The MICs of OPC 17116 for 90% of Mycoplasma pneumoniae (0.25 microgram/ml) and Mycoplasma hominis (0.125 micrograms/ml) isolates tested were closely similar to those of sparfloxacin and were four- to eightfold greater than those of ofloxacin. Temafloxacin was two- to fourfold more active than ofloxacin. Ureaplasma urealyticum was less susceptible; the MICs of OPC 17116 and temafloxacin for 90% of isolates tested were 2 and 4.0 micrograms/ml, respectively.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference14 articles.
1. In vitro activity of sparfloxacin (CI-978, AT-4140, and PD 131501), a quinolone with high activity against gram-positive bacteria;Cohen M. A.;Diagn. Microbiol. Infect. Dis.,1991
2. Fluoroquinolone antimicrobial agents;Hooper D. C.;N. Engl. J. Med.,1991
3. In vitro and in vivo antibacterial activities of a new quinolone, OPC 17116;Imada T.;Antimicrob. Agents Chemother.,1992
4. WIN 57273, a new fluoroquinolone with enhanced in vitro activity versus grampositive pathogens;Kaatz G. W.;Antimicrob. Agents Chemother.,1990
5. Kenny G. E. 1991. Mycoplasmas p. 478-482 1263-1264 1280. In A. Balows W. J. Hausler Jr. K. L. Herrman H. D. Isenberg and H. J. Shadomy (ed.) Manual of clinical microbiology 5th ed. American Society for Microbiology Washington D.C.
Cited by
33 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献