Affiliation:
1. Cleveland Clinic Foundation, Ohio 44195.
Abstract
In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less active against ceftazidime-resistant isolates of Enterobacter cloacae. The MIC90 of FK-037 for methicillin-resistant staphylococci was > 16 micrograms/ml.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. Eng R. H. K. S. M. Smith and C. E. Cherubin. 1992. FK-037 activity for methicillin-resistant Staphylococcus aureus as compared to cefazolin methicillin and vancomycin. Program Abstr. 32nd Intersci. Conf. Antimicrob. Agents Chemother. abstr. 397 p. 177.
2. In vitro and in vivo antibacterial activities of FK037, a novel parenteral broad-spectrum cephalosporin;Fu K. P.;Antimicrob. Agents Chemother.,1993
3. Activity of cefepime against ceftazidime- and cefotaxime-resistant gram-negative bacteria and its relationship to P-lactamase levels;Fung-Tomc J.;Antimicrob. Agents Chemother.,1989
4. Goto S. S. Higashi S. Miyazaki Y. Kaneko and K. Yamaguchi. 1991. FK037 a new parenteral cephalosporin: in vitro and in vivo antibacterial activity. Program Abstr. 31st Intersci. Conf. Antimicrob. Agents Chemother. abstr. 856 p. 241.
5. Inoue K. Y. Hamana and S. Mitsuhashi. 1991. In-vitro antibacterial activity of FK037 a new cephalosporin. Program Abstr. 31st Intersci. Conf. Antimicrob. Agents Chemother. abstr. 854 p. 241.
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