Author:
Retamar Pilar,López-Cerero Lorena,Muniain Miguel Angel,Pascual Álvaro,Rodríguez-Baño Jesús,
Abstract
ABSTRACTWe investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producingEscherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a MIC of ≤2 mg/liter than for isolates with a higher MIC (0% versus 41.1%;P= 0.02).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference8 articles.
1. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern;Pitout;Lancet Infect. Dis,2008
2. β-Lactam/β-lactam inhibitor combinations for the treatment of bacteraemia due to extended-spectrum β-lactamase-producing Escherichia coli: a post hoc analysis of prospective cohorts;the Extended-Spectrum Beta-Lactamases—Red Española de Investigación en Patología Infecciosa/Grupo de Estudio de Infección Hospitalaria Group;Clin. Infect. Dis,2012
3. European Committee on Antimicrobial Susceptibility Testing. 2013. Breakpoint tables for interpretation of MICs and zone diameters, version 3.1. http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/Breakpoint_table_v_3.1.pdf.
4. European Committee on Antimicrobial Susceptibility Testing. 2013. MIC and inhibition zone diameter distributions of microorganisms without and with resistance mechanisms. http://mic.eucast.org/Eucast2/.
5. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis;SAEI/SAMPAC Bacteremia Group;Antimicrob. Agents Chemother,2012
Cited by
80 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献