Longitudinally Tracking Fluoroquinolone Resistance and Its Determinants in Penicillin-Susceptible and -Nonsusceptible Streptococcus pneumoniae Isolates in Hong Kong, 2000 to 2005

Author:

Ip Margaret1,Chau Shirley S. L.1,Chi Fang1,Cheuk Edmund S. C.1,Ma Helen1,Lai Raymond W. M.1,Chan Paul K.1

Affiliation:

1. Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

Abstract

ABSTRACT Of 1,388 Streptococcus pneumoniae isolates collected from 2000 to 2005, 10.5% had a ciprofloxacin MIC of ≥4.0 μg/ml and 1.6% (range, 0.8% to 4.3% per year) had a levofloxacin MIC of ≥4.0 μg/ml. Molecular characterization indicated that fluoroquinolone resistance occurred independently in our prevalent Spain 23F -1 clone, expressing serotypes 23F, 19F, and 14. Rates of resistance to levofloxacin in S. pneumoniae have remained stable at a Hong Kong hospital.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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