Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells-Reference-Cited by-同舟云学术

Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells

Published:2022-10-12 Issue:19 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pagani Isabel¹^ORCID,Ottoboni Linda¹,Podini Paola¹,Ghezzi Silvia¹,Brambilla Elena¹,Bezukladova Svetlana¹,Corti Davide²,Bianchi Marco Emilio¹³,Capobianchi Maria Rosaria⁴,Poli Guido¹³,Panina-Bordignon Paola¹³,Yates Edwin A.⁵,Martino Gianvito¹³,Vicenzi Elisa¹^ORCID

Affiliation:

1. San Raffaele Scientific Institute, Milan, Italy

2. Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland

3. Vita-Salute San Raffaele University, School of Medicine, Milan, Italy

4. National Institute for Infectious Diseases, “Lazzaro Spallanzani,” IRCCS, Rome, Italy

5. Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Liverpool, United Kingdom

Abstract

ZIKV is a neurotropic virus that invades neural progenitor cells (NPCs), causing inhibition of their proliferation and maturation into neurons and glial cells. We have shown previously that heparin, an anticoagulant also used widely during pregnancy, prevents ZIKV-induced cell death with negligible inhibition of virus replication.

Funder

Ministero della Salute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01122-22

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