Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects

Author:

Wen Wei12ORCID,Zheng Zixuan12,Wang Haoyuan12,Zhao Qiongqiong12,Yin Mengge12,Chen Huanchun1234,Li Xiangmin1234,Qian Ping1234ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, China

2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China

3. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei, China

4. Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, Hubei, China

Abstract

DHX30, an RNA helicase, is identified as a 3C pro -interacting protein regulating Seneca Valley virus (SVV) replication dependent on its helicase activity. DHX30 functioned as a viral-RNA binding protein that inhibited SVV replication at the early stage of virus infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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