Frur mediates catabolite activation of pyruvate kinase (pykF) gene expression in Escherichia coli

Author:

Bledig S A1,Ramseier T M1,Saier M H1

Affiliation:

1. Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.

Abstract

Expression of a pykF-lacZ fusion was studied as a function of the carbon source in wild-type strains and strains lacking or overproducing the FruR protein of Escherichia coli. FruR controls the response to the carbon source by repressing pykF expression more strongly under gluconeogenic than under glycolytic conditions, a phenomenon we term catabolite activation.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference18 articles.

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4. Evidence for regulation of gluconeogenesis by the fructose phosphotransferase system in Salmonella typhimurium;Chin A. M.;J. Bacteriol.,1987

5. In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling glyoxylate shunt enzyme synthesis;Cortay J.;J. Biol. Chem.,1994

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