Sequential Linezolid-Resistant Staphylococcus epidermidis Isolates with G2576T Mutation-Reference-Cited by-同舟云学术

Sequential Linezolid-Resistant Staphylococcus epidermidis Isolates with G2576T Mutation

Published:2007-10 Issue:10 Volume:45 Page:3277-3280
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Hong Tao¹,Li Xiangyang¹,Wang Jie¹,Sloan Cynthia¹,Cicogna Cristina²

Affiliation:

1. Clinical Microbiology, Department of Pathology

2. Division of Infectious Diseases, Hackensack University Medical Center, Hackensack, New Jersey

Abstract

ABSTRACT We report on an analysis of sequential isolates of Staphylococcus epidermidis from cultures of blood obtained from a patient with acute myeloid leukemia while the patient was receiving linezolid treatment. All 12 isolates had a linezolid MIC of 32 μg/ml. A 420-bp domain V region of the 23S rRNA gene from all isolates was amplified, and their nucleotide sequences were determined. A G2576T mutation was identified in all isolates. It was estimated that 67% of the 23S rRNA genes carried this mutation. This is the first report of the failure of linezolid treatment for Staphylococcus epidermidis bacteremia associated with a G2576T mutation in an immunocompromised patient.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02048-06

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