Human Immunodeficiency Virus (HIV) and Human Cytomegalovirus (HCMV) Coinfection of Infant Tonsil Epithelium May Synergistically Promote both HIV-1 and HCMV Spread and Infection-Reference-Cited by-同舟云学术

Human Immunodeficiency Virus (HIV) and Human Cytomegalovirus (HCMV) Coinfection of Infant Tonsil Epithelium May Synergistically Promote both HIV-1 and HCMV Spread and Infection

Published:2021-08-25 Issue:18 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sufiawati Irna¹,Herrera Rossana²,Mayer Wasima²,Cai Xiaodan²,Borkakoti Jayanta²,Lin Vicky²,Rosbe Kristina³,Tugizov Sharof M.²^ORCID

Affiliation:

1. Department of Oral Medicine, Faculty of Dentistry, University of Padjadjaran, Bandung, Indonesia

2. Department of Medicine, University of California—San Francisco, San Francisco, California, USA

3. Department of Otolaryngology, University of California—San Francisco, San Francisco, California, USA

Abstract

Most HIV-1 and HCMV MTCT occurs in infancy, and the cotransmission of these viruses may occur via infant oropharyngeal and tonsil epithelia, which are the first biological barriers for viral pathogens. We have shown that HIV-1 and HCMV disrupt epithelial junctions, reducing the barrier functions of epithelia and thus allowing paracellular penetration of both viruses via mucosal epithelia.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00921-21

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