Trypsin-Enhanced Infection with Porcine Epidemic Diarrhea Virus Is Determined by the S2 Subunit of the Spike Glycoprotein-Reference-Cited by-同舟云学术

Trypsin-Enhanced Infection with Porcine Epidemic Diarrhea Virus Is Determined by the S2 Subunit of the Spike Glycoprotein

Published:2021-05-10 Issue:11 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tan Yubei¹²,Sun Limeng¹²,Wang Gang¹²,Shi Yuejun¹²,Dong Wanyu³,Fu Yanan¹²,Fu Zhen¹²,Chen Huanchun¹²,Peng Guiqing¹²^ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

2. Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China

3. Department of Veterinary Medicine, College of Animal Science and Technology, Zhejiang A&F University, Hangzhou, China

Abstract

With the emergence of new variants, PEDV remains a major problem in the global swine industry. Efficient PEDV infection usually requires trypsin, but the mechanism of trypsin dependency is complex.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

Huazhong Agricultural University

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02453-20

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