Circumvention of Herd Immunity during an Outbreak of Meningococcal Disease Could Be Correlated to Escape Mutation in the porA Gene of Neisseria meningitidis-Reference-Cited by-同舟云学术

Circumvention of Herd Immunity during an Outbreak of Meningococcal Disease Could Be Correlated to Escape Mutation in the porA Gene of Neisseria meningitidis

Published:2001-03 Issue:3 Volume:69 Page:1971-1973
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Taha Muhamed-Kheir¹,Bichier Edouard²,Perrocheau Anne³,Alonso Jean-Michel¹

Affiliation:

1. Unité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, 75724 Paris Cedex 15,1

2. Laboratoire du Centre Hospitalier de Saumur, 49403 Saumur Cedex,2 and

3. Institut de Veille Sanitaire, 94415 Saint Maurice Cedex,3 France

Abstract

ABSTRACT Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.3.1971-1973.2001

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