Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats-Reference-Cited by-同舟云学术

Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Qu Shaoqi¹²,Dai Cunchun¹²,Lang Fengting¹²,Hu Longfei¹²,Tang Qihe¹²,Wang Haixia¹²,Zhang Yanping¹²,Hao Zhihui¹²

Affiliation:

1. Agricultural Bio-pharmaceutical Laboratory, Qingdao Agricultural University, Qingdao, China

2. National-Local Joint Engineering Laboratory of Agricultural Bio-pharmaceutical Technology, Qingdao, China

Abstract

Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats.

Funder

National Key Research and Development Foundation Plan

Startup and Innovation Leader Talent Plan of Qingdao

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01545-18

Reference51 articles.

1. Risk factors for nephrotoxicity associated with continuous vancomycin infusion in outpatient parenteral antibiotic therapy

2. Vancomycin: A 50-Year Reassessment