A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate-Reference-Cited by-同舟云学术

A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cavalheiro Mafalda¹²,Costa Catarina¹²,Silva-Dias Ana³⁴,Miranda Isabel M.³⁴,Wang Can⁵,Pais Pedro¹²,Pinto Sandra N.²⁶,Mil-Homens Dalila¹²,Sato-Okamoto Michiyo⁷,Takahashi-Nakaguchi Azusa⁷,Silva Raquel M.⁸,Mira Nuno P.¹²,Fialho Arsénio M.¹²,Chibana Hiroji⁷,Rodrigues Acácio G.³⁴,Butler Geraldine⁵^ORCID,Teixeira Miguel C.¹²^ORCID

Affiliation:

1. Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

2. iBB—Institute for Bioengineering and Biosciences, Biological Sciences Research Group, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

3. Department of Pathology, Division of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal

4. CINTESIS—Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal

5. School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland

6. Centro de Química-Física Molecular, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

7. Medical Mycology Research Center, Chiba University, Chiba, Japan

8. Department of Medical Sciences, iBiMED and IEETA, University of Aveiro, Aveiro, Portugal

Abstract

Candida glabrata is an emerging fungal pathogen. Its increased prevalence is associated with its ability to rapidly develop antifungal drug resistance, particularly to azoles.

Funder

Science Foundation Ireland

MEC | Fundação para a Ciência e a Tecnologia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00995-18

Reference52 articles.

1. Emerging and Emerged Pathogenic Candida Species: Beyond the Candida albicans Paradigm

2. Candida glabrata : Review of Epidemiology, Pathogenesis, and Clinical Disease with Comparison to C. albicans