Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities-Reference-Cited by-同舟云学术

Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Morrisette Taylor¹^ORCID,Lev Katherine L.¹,Kebriaei Razieh¹,Abdul-Mutakabbir Jacinda C.¹,Stamper Kyle C.¹,Morales Sandra²,Lehman Susan M.³,Canfield Gregory S.⁴⁵,Duerkop Breck A.⁵^ORCID,Arias Cesar A.⁶⁷⁸,Rybak Michael J.¹⁹¹⁰^ORCID

Affiliation:

1. Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA

2. Phage Consulting, Sydney, New South Wales, Australia

3. Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

4. Department of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA

5. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

6. Division of Infectious Diseases and Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), UTHealth, McGovern Medical School, Houston, Texas, USA

7. Center for Infectious Diseases, UTHealth, School of Public Health, Houston, Texas, USA

8. Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia

9. Division of Infectious Diseases, Department of Medicine, Wayne State University, Detroit, Michigan, USA

10. Department of Pharmacy, Detroit Medical Center, Detroit, Michigan, USA

Abstract

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium . After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00993-20

Reference33 articles.

1. Impact of Enterococcal Bacteremia in Liver Transplant Recipients

2. The importance of adjusting for enterococcus species when assessing the burden of vancomycin resistance: a cohort study including over 1000 cases of enterococcal bloodstream infections

3. Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014