Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure-Reference-Cited by-同舟云学术

Apparent Absence of Selective Pressure on Pneumocystis jirovecii Organisms in Patients with Prior Methotrexate Exposure

Published:2022-12-20 Issue:12 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bonnet Pierre L.¹²^ORCID,Le Gal Solène¹²,Gautier Chloé²,Hoffmann Claire V.¹²,Le Nan Nathan¹²,Happe André³,Le Berre Rozenn⁴⁵,Saraux Alain⁶⁷,Nevez Gilles¹²^ORCID

Affiliation:

1. Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France

2. Fungal Respiratory Infections (FRI) Research Unit, University of Angers, University of Western Brittany, Brest, France

3. Clinical Data Center, Brest University Hospital, Brest, France

4. Department of Internal and Respiratory Medicine, Brest University Hospital, Brest, France

5. University of Western Brittany, INSERM, UMR 1078, GGB, Brest, France

6. Department of Rheumatology, Brest University Hospital, Brest, France

7. University of Western Brittany, INSERM, UMR 1227, Brest, France

Abstract

Pneumocystis jirovecii infections occur in patients treated with methotrexate (MTX) because of immunosuppressive effects of this highly potent dihydrofolate reductase (DHFR) inhibitor. Conversely, MTX may act as an anti -P. jirovecii drug and consequently may exert a selective pressure on this fungus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00990-22

Reference28 articles.

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2. Pneumocystis jiroveciiPneumonia in Patients with or without AIDS, France

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