Ability of monophosphoryl lipid A to augment the antibody response of young mice-Reference-Cited by-同舟云学术

Ability of monophosphoryl lipid A to augment the antibody response of young mice

Published:1988-12 Issue:12 Volume:56 Page:3064-3066
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Baker P J¹,Hiernaux J R¹,Fauntleroy M B¹,Stashak P W¹,Prescott B¹,Cantrell J L¹,Rudbach J A¹

Affiliation:

1. Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

Abstract

Treatment with nontoxic monophosphoryl lipid A increased the magnitude of the immunoglobulin M (IgM) antibody response to type III pneumococcal polysaccharide in young (2- to 4-week-old) mice. This was accompanied by the appearance of significant numbers of IgG1- and IgG3- secreting antibody-forming cells in 4-week-old mice. These findings indicate that monophosphoryl lipid A can be used as an adjuvant to improve the immunogenicity of poorly immunogenic antigens in young, immunologically immature animals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.56.12.3064-3066.1988

Reference28 articles.

1. Regulation of the antibody response to type III pneumococcal polysaccharide;Baker P. J.;Rev. Infect. Dis.,1981

2. Inactivation of suppressor T-cell activity by nontoxic monophosphoryl lipid A;Baker P. J.;Infect. Immun.,1988

3. Baker P. J. and B. Prescott. 1979. Regulation of the antibody response to pneumococcal polysaccharides by thymus-derived (T) cells: mode of action of suppressor and amplifier T cells p. 67-105. In J. A. Rudbach and P. J. Baker (ed.) Immunology of bacterial polysaccharides. Elsevier/North Holland Publishing Co. New York.

4. Characterization of the antibody response to type III pneumococcal polysaccharide at the cellular level. III. Studies on the average avidity of the antibody produced by specific plaque-forming cells;Baker P. J.;J. Immunol.,1971

5. Quantitative and qualitative studies on the primary antibody response to pneumococcal polysaccharide at the cellular level;Baker P. J.;J. Immunol.,1969

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