Affiliation:
1. Department of Pathology, University of California, Irvine 92717.
Abstract
Peritoneal mouse macrophages activated in vitro with recombinant murine gamma interferon (10 ng/ml) or in vivo (10 micrograms per mouse) showed a significant decrease in the growth and yield of Chlamydia trachomatis. The restriction of the growth of C. trachomatis paralleled the expression of Iad on the macrophages. Mice that received macrophages activated in vitro with recombinant murine gamma interferon showed a significant decrease in the yield of chlamydial infection-forming units from their spleens and peritoneal fluids.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference19 articles.
1. Growth of meningopneumonitis virus in normal and immune guinea pig monocytes;Benedict A. A.;Nature (London),1958
2. In vivo and in vitro activation of alveolar macrophages by recombinant interferon-y;Black C. M.;J. Immunol.,1987
3. Burton L. E. P. W. Gary D. V. Goeddel and E. Rinderknecht. 1984. Modifications of recombinant human and murine IFN-y and their biochemical characteristics p. 403-409. In H. Kirchner and H. Schellekens (ed.) The biology of the interferon system. Elsevier Biomedical Press Amsterdam.
4. Inhibition of Chlamydia psittaci in oxidatively active thioglycolate-elicited macrophages: distinction between Iymphokine-mediated oxygen-dependent and oxygen-independent macrophage activation;Byrne G. I.;Infect. Immun.,1983
5. The antichlamydial, antiviral, and antiproliferative activities of human gamma interferon are dependent on the integrity of the C terminus of the interferon molecule;de la Maza L. M.;Infect. Immun.,1987
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