Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii-Reference-Cited by-同舟云学术

Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii

Published:1989-01 Issue:1 Volume:33 Page:30-34
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Israelski D M¹,Tom C¹,Remington J S¹

Affiliation:

1. Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.

Abstract

The effect of zidovudine (azidothymidine; AZT) on the action of pyrimethamine against Toxoplasma gondii was investigated. Zidovudine was found to antagonize the toxoplasmacidal effect of low concentrations of pyrimethamine in vitro, and in vitro synergism of pyrimethamine and sulfadiazine against T. gondii was reversed by zidovudine. Zidovudine also antagonized the therapeutic effect of pyrimethamine in mice acutely infected with T. gondii.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.33.1.30

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