Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391-Reference-Cited by-同舟云学术

Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391

Published:1989-12 Issue:12 Volume:33 Page:2157-2159
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Inoue E¹,Mitsuhashi S¹

Affiliation:

1. Episome Institute, Gunma, Japan.

Abstract

The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.33.12.2157

Reference10 articles.

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