Affiliation:
1. Antibiotic Research Unit, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0581.
Abstract
Cations such as magnesium and aluminum significantly impair the absorption of ciprofloxacin. Twelve healthy adult male volunteers participated in this four-way crossover study to investigate the effects of ferrous sulfate and multivitamins with zinc on the absorption of ciprofloxacin. Doses of ciprofloxacin (500 mg) were given 7 days apart and after an overnight fast. Dose 1 was administered alone (regimen A). The subjects then received either a ferrous sulfate tablet (325 mg three times a day; regimen B) or a once-daily multivitamin with zinc (regimen C) for 7 days; dose 2 of ciprofloxacin was then given with the last dose of regimen B or C. Subjects were crossed over to the alternate regimen for 7 days, and dose 3 of ciprofloxacin was again administered with the last dose of regimen B or C. After a 7-day washout, dose 4 of ciprofloxacin was given (regimen D). Ciprofloxacin concentrations were determined by high-pressure liquid chromatography. The areas under the concentration-time curve (AUCs) of ciprofloxacin for regimens A and D were not significantly different (14.5 +/- 2.3 versus 15.7 +/- 2.8 micrograms.h/ml, mean +/- standard deviation). The AUCs for regimen B (5.4 +/- 1.7 micrograms.h/ml) and regimen C (11.3 +/- 2.4 micrograms.h/ml) were significantly different from the AUCs for regimens A and D. Peak concentrations of ciprofloxacin with regimen B were below the MIC for 90% of strains of many organisms normally considered susceptible. Ferrous sulfate and multivitamins with zinc significantly impaired the absorption of ciprofloxacin. The effect of ferrous sulfate is likely to be clinically significant; the responsible component of multivitamins with zinc requires additional study.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference14 articles.
1. Barriere S. L. 1987. Economic impact of oral ciprofloxacin: a pharmacist's perspective. Am. J. Med. 82(Suppl. 4A):387-390.
2. Alteration of methyldopa absorption, metabolism, and blood pressure control caused by ferrous sulfate and ferrous gluconate;Campbell N.;Clin. Pharmacol. Ther.,1988
3. Routes of quinolone permeation in Escherichia coli;Chapman J. S.;Antimicrob. Agents Chemother.,1988
4. Effects of antacids and dialysate dwell times on multiple-dose pharmacokinetics of oral ciprofloxacin in pa- tients on continuous ambulatory peritoneal dialysis;Golper T. A.;Antimicrob. Agents Chemother.,1987
5. Pharmacokinetics and bioavailability of ciprofloxacin and ofloxacin: effects of food and antacid intake;Hoffken G.;Rev. Infect. Dis.,1988
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