Conserved E1B-55K SUMOylation in Different Human Adenovirus Species Is a Potent Regulator of Intracellular Localization-Reference-Cited by-同舟云学术

Conserved E1B-55K SUMOylation in Different Human Adenovirus Species Is a Potent Regulator of Intracellular Localization

Published:2022-02-09 Issue:3 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kolbe Viktoria¹,Ip Wing H.¹^ORCID,Kieweg-Thompson Lisa¹,Lang Judith¹,Gruhne Julia¹,Meyer Tina¹,Wilkens Britta¹,Schie Marcel²³,Thünauer Roland²,Schreiner Sabrina⁴⁵⁶,Bertzbach Luca D.¹^ORCID,Rodríguez Estefanía¹⁷⁸,Dobner Thomas¹

Affiliation:

1. Department of Viral Transformation, Leibniz Institute for Experimental Virology (HPI), Hamburg, Germany

2. Technology Platform Microscopy and Image Analysis, Leibniz Institute for Experimental Virology (HPI), Hamburg, Germany

3. Leibniz ScienceCampus InterACt, Hamburg, Germany

4. Institute of Virology, Hannover Medical School, Hannover, Germany

5. Cluster of Excellence RESIST (Resolving Infection Susceptibility; EXC 2155), Hannover Medical School, Hannover, Germany

6. Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany

7. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

8. German Centre for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Braunschweig, Germany

Abstract

E1B-55K is a multifunctional adenoviral protein and its functions are highly regulated by SUMOylation. Although functional consequences of SUMOylated HAdV-C5 E1B-55K are well studied, we lack information on the effects of SUMOylation on homologous E1B-55K proteins from other HAdV species.

Funder

Freie und Hansestadt Hamburg

Bundesministerium für Gesundheit

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00838-21

Reference59 articles.

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2. The biology of the adenovirus E1B 55K protein

3. SUMO junction—what's your function?

4. Adenovirus E1B 55K Represses p53 Activation In Vitro

5. The adenovirus E1B-55K oncoprotein induces SUMO modification of p53

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