IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication-Reference-Cited by-同舟云学术

IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication

Published:2021-09-27 Issue:20 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Meischel Tina¹,Fritzlar Svenja¹,Villalon-Letelier Fernando¹,Tessema Melkamu B.¹,Brooks Andrew G.¹,Reading Patrick C.¹²,Londrigan Sarah L.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

2. WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

Abstract

Interferon-induced transmembrane (IFITM) proteins restrict the initial stages of infection for several respiratory viruses; however, their potential to modulate the later stages of virus replication has not been explored. In this study, we highlight the utility of an inducible overexpression system to assess the impact of IFITM proteins on either early- or late-stage replication of two respiratory viruses.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00837-21

Reference52 articles.

1. IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

2. IFITMs Restrict the Replication of Multiple Pathogenic Viruses

3. IFITM3 Restricts Human Metapneumovirus Infection