NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation

Author:

Dominguez Francisco1,Shiliaev Nikita1,Lukash Tetyana1,Agback Peter2,Palchevska Oksana1,Gould Joseph R.1,Meshram Chetan D.1,Prevelige Peter E.1,Green Todd J.1ORCID,Agback Tatiana2,Frolova Elena I.1ORCID,Frolov Ilya1ORCID

Affiliation:

1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden

Abstract

Cellular proteins play critical roles in the assembly of alphavirus replication complexes (vRCs). Their recruitment is determined by the viral nonstructural protein 3 (nsP3).

Funder

Swedish Foundation for Strategic Research

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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