IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism-Reference-Cited by-同舟云学术

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism

Published:2019-04 Issue:7 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Regué Laura¹²³,Ji Fei¹⁴,Flicker Daniel¹⁵,Kramer Dana⁶,Pierce William¹,Davidoff Teekhon¹,Widrick Jeffrey J.⁷⁸,Houstis Nicholas⁹³,Minichiello Liliana⁶¹⁰,Dai Ning¹²³,Avruch Joseph¹²³

Affiliation:

1. Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA

2. Diabetes Unit of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA

3. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

4. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

5. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

6. European Molecular Biology Laboratory, Mouse Biology Unit, Monterotondo, Italy

7. Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Boston, Massachusetts, USA

8. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

9. Cardiac Unit of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts, USA

10. Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Abstract

Insulin-like growth factor 2 (IGF2) mRNA binding protein 2 (IMP2) was selectively deleted from adult mouse muscle; two phenotypes were observed: decreased accrual of skeletal muscle mass after weaning and reduced wheel-running activity but normal forced treadmill performance. Reduced wheel running occurs when mice are fed a high-fat diet but is normalized when mice consume standard chow.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Lundbeckfonden

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00528-18

Reference60 articles.

1. IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

2. mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry