Drosophila melanogaster Thor and Response to Candida albicans Infection-Reference-Cited by-同舟云学术

Drosophila melanogaster Thor and Response to Candida albicans Infection

Published:2007-04 Issue:4 Volume:6 Page:658-663
ISSN:1535-9778
Container-title:Eukaryotic Cell
language:en
Short-container-title:Eukaryot Cell

Author:

Levitin A.¹,Marcil A.¹,Tettweiler G.²,Laforest M. J.¹,Oberholzer U.¹,Alarco A. M.¹,Thomas D. Y.³,Lasko P.²,Whiteway M.¹²

Affiliation:

1. Genetics Group, Biotechnology Research Institute, National Research Council, Montreal, Quebec H4P 2R2, Canada

2. Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada

3. Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada

Abstract

ABSTRACT We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans . Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E - BP null mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.

Publisher

American Society for Microbiology

Subject

Molecular Biology,General Medicine,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/EC.00346-06

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