Multicenter Comparison of Nucleic Acid Amplification Tests for the Diagnosis of Rectal and Oropharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae Infections

Author:

Van Der Pol Barbara1ORCID,Chernesky Max2,Gaydos Charlotte A.3,Hook Edward W.1,Joseph Ajith M.4,Christensen Katherine5,Arcenas Rodney6,Boutwell Alexander1,Wiesenfeld Harold C.7,Taylor Stephanie N.8,Mayer Kenneth H.9,Golden Matthew R.10,Moncada Jeanne11,Jang Dan2,Schachter Julius11,

Affiliation:

1. University of Alabama School of Medicine, Birmingham, Alabama, USA

2. McMaster University, St Joseph’s Healthcare, Hamilton, Ontario, Canada

3. Johns Hopkins School of Medicine, Baltimore, Maryland, USA

4. Abbott, Medical Affairs, Lake Forest, Illinois, USA

5. Becton, Dickinson and Company, BD Life Sciences – Integrated Diagnostic Sciences Solutions, Sparks, Maryland, USA

6. Roche Diagnostic Systems, Pleasanton, California, USA

7. University of Pittsburgh School of Medicine and Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA

8. Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

9. Fenway Health, Boston Massachusetts, USA

10. University of Washington, Seattle, Washington, USA

11. University of California-San Francisco, San Francisco, California, USA

Abstract

Research using nucleic acid amplification tests (NAATs) have repeatedly found rectal and oropharyngeal infections with Chlamydia trachomatis and Neisseria gonorrhoeae to be common and potentially more difficult to treat than genital infections. Unfortunately, public health and patient care efforts have been hampered by the lack of FDA-cleared NAATs with claims for anorectal or oropharyngeal samples.

Funder

Abbott | Abbott Molecular

BD Biosciences

Roche Holding | Roche Diagnostics

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference25 articles.

1. Guidelines for treatment of sexually transmitted diseases;Centers for Disease Control and Prevention;MMWR Recomm Rep,1998

2. Prevalence of Rectal, Urethral, and Pharyngeal Chlamydia and Gonorrhea Detected in 2 Clinical Settings among Men Who Have Sex with Men: San Francisco, California, 2003

3. Nucleic Acid Amplification Tests in the Diagnosis of Chlamydial and Gonococcal Infections of the Oropharynx and Rectum in Men Who Have Sex With Men

4. Sexually transmitted diseases treatment guidelines 2010 Centers for Disease Control and Prevention

5. Van der Pol B. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae-2014;Papp JR;MMWR Recomm Rep,2014

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