BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells-Reference-Cited by-同舟云学术

BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells

Published:2015-05-15 Issue:10 Volume:89 Page:5739-5746
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cojohari Olesea¹,Burrer Christine M.¹,Peppenelli Megan A.¹,Abulwerdi Fardokht A.²,Nikolovska-Coleska Zaneta²,Chan Gary C.¹^ORCID

Affiliation:

1. Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse, New York, USA

2. Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

ABSTRACT Herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and Kaposi’s sarcoma-associated herpesvirus, establish latency by modulating or mimicking antiapoptotic Bcl-2 proteins to promote survival of carrier cells. BH3 profiling, which assesses the contribution of Bcl-2 proteins towards cellular survival, was able to globally determine the level of dependence on individual cellular and viral Bcl-2 proteins within latently infected cells. Moreover, BH3 profiling predicted the sensitivity of infected cells to small-molecule inhibitors of Bcl-2 proteins.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00236-15

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