Nucleolin Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus by Supporting the Assembly of Translation Initiation Complexes-Reference-Cited by-同舟云学术

Nucleolin Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus by Supporting the Assembly of Translation Initiation Complexes

Published:2021-06-10 Issue:13 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Han Shichong¹²³^ORCID,Wang Xiaojia²,Guan Junyong¹,Wu Jinen¹,Zhang Yun¹,Li Pinghua¹,Liu Zaixin¹,Abdullah Sahibzada Waheed¹,Zhang Zhihui¹,Jin Ye¹,Sun Shiqi¹,Guo Huichen¹⁴

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology, OIE/China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, People’s Republic of China

2. Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, People’s Republic of China

3. International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, People’s Republic of China

4. College of Animal Science, Yangtze University, Jingzhou, Hubei, People’s Republic of China

Abstract

FMDV usurps the cellular translation machinery to initiate viral protein synthesis via a mechanism driven by IRES elements. It allows the virus to shut down bulk cellular translation, while providing an advantage for its own gene expression.

Funder

Central Public-interest Scientific Institution Basal Research Fund

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00238-21

Reference64 articles.

1. Bridging IRES elements in mRNAs to the eukaryotic translation apparatus

2. Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets