Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection-Reference-Cited by-同舟云学术

Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection

Published:2011-05-15 Issue:10 Volume:85 Page:5202-5207
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Shinya Kyoko¹²,Makino Akiko¹,Hatta Masato²,Watanabe Shinji²,Kim Jin Hyun²,Hatta Yasuko²,Gao Peng²,Ozawa Makoto²³,Le Quynh Mai⁴,Kawaoka Yoshihiro¹²⁵⁶³

Affiliation:

1. Division of Zoonosis, Department of Microbiology and Infectious Disease, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan

2. Influenza Research Institute, Department of Pathological Sciences, University of Wisconsin—Madison, Madison, Wisconsin

3. International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan

4. National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

5. ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan

6. Division of Virology, Department of Microbiology and Immunology

Abstract

ABSTRACT Although H5N1 influenza A viruses can cause systemic infection, their neurotropism and long-term effects on the central nervous system (CNS) are not fully understood. We assessed H5N1viral invasion of the CNS and its long-term effects in a ferret model. An H5N1 virus caused nonsuppurative encephalitis, which lasted for 3 months without neurologic signs. Further, another H5N1 virus caused nonsuppurative vasculitis with brain hemorrhage. Three-dimensional analysis of viral distribution in the brain identified the olfactory system as a major route for brain invasion. The efficient growth of virus in the upper respiratory tract may thus facilitate viral brain invasion.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00239-11

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