Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest-Reference-Cited by-同舟云学术

Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barnes Kay B.¹,Zumbrun Steven D.²,Halasohoris Stephanie A.²,Desai Purvi D.²,Miller Lynda L.²,Richards Mark I.¹,Russell Paul¹,Bentley Christine³,Harding Sarah V.¹

Affiliation:

1. Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom

2. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA

3. MerLion Pharmaceuticals, Berlin, Germany

Abstract

This study investigated the in vitro activity of finafloxacin against bacterial strain panels of the biodefense pathogens. Broth microdilution assays were performed at neutral and acidic pH to determine the effectiveness of the antibiotics under conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH.

Funder

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01470-19

Reference18 articles.

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2. Erythromycin Modification That Improves Its Acidic Stability while Optimizing It for Local Drug Delivery

3. The Influence of Urinary pH on Antibiotic Efficacy Against Bacterial Uropathogens