Expression of a Structural Protein of the Mycovirus FgV-ch9 Negatively Affects the Transcript Level of a Novel Symptom Alleviation Factor and Causes Virus Infection-Like Symptoms in Fusarium graminearum

Author:

Bormann Jörg12ORCID,Heinze Cornelia1,Blum Christine1,Mentges Michael1,Brockmann Anke1,Alder Arne1,Landt Svenja Kim1,Josephson Brian2,Indenbirken Daniela3,Spohn Michael3,Plitzko Birte4,Loesgen Sandra4,Freitag Michael2,Schäfer Wilhelm1

Affiliation:

1. University of Hamburg, Biocenter Klein Flottbek, Department of Molecular Phytopathology, Hamburg, Germany

2. Oregon State University, Department of Biochemistry and Biophysics, Corvallis, Oregon, USA

3. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany

4. Oregon State University, Department of Chemistry, Corvallis, Oregon, USA

Abstract

Virus infections of phytopathogenic fungi occasionally impair growth, reproduction, and virulence, a phenomenon referred to as hypovirulence. Hypovirulence-inducing mycoviruses, therefore, represent a powerful means to defeat fungal epidemics on crop plants. However, the poor understanding of the molecular basis of hypovirulence induction limits their application. Using the devastating fungal pathogen on cereal crops, Fusarium graminearum , we identified an mRNA binding protein (named virus response 1, vr1 ) which is involved in symptom expression. Downregulation of vr1 in the virus-infected fungus and vr1 deletion evoke virus infection-like symptoms, while constitutive expression overrules the cytopathic effects of the virus infection. Intriguingly, the presence of a specific viral structural protein is sufficient to trigger the fungal response, i.e., vr1 downregulation, and symptom development similar to virus infection. The advancements in understanding fungal infection and response may aid biological pest control approaches using mycoviruses or viral proteins to prevent future Fusarium epidemics.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference53 articles.

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4. Nuss D. 2011. Mycoviruses, p 145–152. In Borkovich K, Ebbole D (ed), Cellular and molecular biology of filamentous fungi. ASM Press, Washington, DC.

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