Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile-Reference-Cited by-同舟云学术

Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile

Published:2019-02 Issue:2 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

van Eijk Erika¹^ORCID,Boekhoud Ilse M.¹²³^ORCID,Kuijper Ed J.¹³^ORCID,Bos-Sanders Ingrid M. J. G.¹,Wright George⁴^ORCID,Smits Wiep Klaas¹²³^ORCID

Affiliation:

1. Department of Medical Microbiology, Center for Infectious Diseases Leiden University Medical Center, Leiden, the Netherlands

2. Centre for Microbial Cell Biology, Leiden, the Netherlands

3. Netherlands Centre for One Health‡

4. Acurx Pharmaceuticals, White Plains, New York, USA

Abstract

Clostridium difficile is a potentially lethal gut pathogen that causes nosocomial and community-acquired infections. Limited treatment options and reports of reduced susceptibility to current treatment emphasize the necessity for novel antimicrobials.

Funder

Leiden University Medical Center

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01363-18

Reference68 articles.

1. Reclassification of Clostridium difficile as Clostridioides difficile (Hall and O’Toole 1935) Prévot 1938

2. Clostridium difficile Infection