Classical Swine Fever Virus N pro Antagonizes IRF3 To Prevent Interferon-Independent TLR3- and RIG-I-Mediated Apoptosis-Reference-Cited by-同舟云学术

Classical Swine Fever Virus N pro Antagonizes IRF3 To Prevent Interferon-Independent TLR3- and RIG-I-Mediated Apoptosis

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hardy Samuel¹²^ORCID,Jackson Ben¹,Goodbourn Stephen²^ORCID,Seago Julian¹^ORCID

Affiliation:

1. The Pirbright Institute, Pirbright, Woking, Surrey, United Kingdom

2. Institute for Infection and Immunity, St. George’s, University of London, London, United Kingdom

Abstract

Responsible for severe hemorrhagic disease in domestic pigs and wild boar, classical swine fever is recognized by the World Organisation for Animal Health (OIE) and European Union as a notifiable disease of economic importance. Persistent infection, immunotolerance, and early dissemination of the virus at local sites of infection have been linked to the antagonism of type I IFN induction by N pro .

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01136-20

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