Affiliation:
1. Department of Microbiology and Natural Products Research, Research Center, Mead Johnson & Company, Evansville, Indiana
Abstract
Zygmunt, Walter
A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of
d
-cycloserine inhibition of mycobacterial growth by
d
-alanine. J. Bacteriol.
85:
1217–1220. 1963.—Reversal of the antimycobacterial activity of
d
-4-amino-3-isoxazolidinone (
d
-cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances,
d
-alanine was the most effective reversal agent. The specificity with which the
d
isomer reversed the antimycobacterial activity of
d
-cycloserine was more pronounced than that observed with other species of bacteria. Mycobactin, a growth factor for certain mycobacteria, showed no reversal activity.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
22 articles.
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