NEISSERIA GONORRHOEAE I

Author:

Kellogg Douglas S.1,Peacock William L.1,Deacon W. E.1,Brown L.1,Pirkle Carl I.1

Affiliation:

1. Venereal Disease Research Laboratory, Venereal Disease Branch, Communicable Disease Center, U.S. Public Health Service, Atlanta, Georgia

Abstract

Kellogg, Douglas S., Jr. (Communicable Disease Center, Atlanta, Ga.), William L. Peacock, Jr., W. E. Deacon, L. Brown, and Carl I. Pirkle . Neisseria gonorrhoeae . I. Virulence genetically linked to clonal variation. J. Bacteriol. 85: 1274–1279. 1963.—One type, obtained from the purulent exudate of acute gonorrhea was maintained by 69 selective in vitro passages, at which point the organisms produced infections in human volunteers. A predominance of clonal types found in laboratory strains and a lack of ability to infect human volunteers resulted from 69 nonselective in vitro passages. Physiological and serological characteristics of the clonal types are compared. We are now in a position to study Neisseria gonorrhoeae organisms in their virulent form.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference5 articles.

1. Identification of Neisseria gonorrhoeae by means of fluorescent antibodies;DEACON W. E.;Proc. Soc. Exptl. Biol. Med.,1959

2. LANKFORD C. E. 1950. Chemically defined nutrient supplements for gonococcus culture media. Bacteriol. Proc. p. 40.

3. The identification of Neisseria gonorrhoeae by means of bacterial variation and the detection of small colony forms in clinical material;MORTON H. E.;J. Bacteriol.,1945

4. NTeisseria and neisserial infections;SCHERP H. W.;Ann. Rev. Microbiol.,1955

5. SOCIETY OF AMERICAN BACTERIOLOGISTS. 1957. Manual of microbiological methods. McGraw-Hill Book Co. Inc. New York.

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