Affiliation:
1. Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University, Narashino, Chiba
Abstract
The mode of action of 5-fluorocytosine on
Candida albicans
and
Saccharomyces cerevisiae
was studied with special reference to morphology and ultrastructure. Shortly after contact of yeast cells with 10 μg of 5-fluorocytosine per ml, marked enlargement of the cells occurred. The initial increase in cell size was almost the same with both yeast strains. As incubation proceeded, further increase in cell volume continued with
C. albicans
, whereas no further change in cell volume was observed with
S. cerevisiae
. An electron microscope examination of
C. albicans
cells after exposure to the drug revealed characteristic changes, consisting of an enlarged nucleus and a thin cell wall. The morphological changes were exactly comparable to those reported with inhibitors of deoxyribonucleic acid synthesis in mammalian cells and some bacteria.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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