The mcr-9 Gene of Salmonella and Escherichia coli Is Not Associated with Colistin Resistance in the United States

Author:

Tyson Gregory H.1ORCID,Li Cong1,Hsu Chih-Hao1,Ayers Sherry1,Borenstein Stacey1,Mukherjee Sampa1,Tran Thu-Thuy1,McDermott Patrick F.1,Zhao Shaohua1

Affiliation:

1. U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA

Abstract

Reports of transmissible colistin resistance show the importance of comprehensive colistin resistance surveillance. Recently, a new allele of the mobile colistin resistance ( mcr ) gene family designated mcr-9 , which shows variation in genetic context and colistin susceptibility, was reported. We tested over 100 Salmonella enterica and Escherichia coli isolates with mcr-9 from the National Antimicrobial Resistance Monitoring System (NARMS) in the United States for their susceptibility to colistin and found that every isolate was susceptible, with an MIC of ≤1 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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