Potential sources of sporadic human infection with Yersinia enterocolitica serovar O:8 in Aomori Prefecture, Japan

Abstract

In November 1992 and June and August 1993 rectal contents from 204 small mammals living in the wild were collected and examined for the presence of Yersinia enterocolitica serovar O:8 to clarify the source of human infections caused by this microbe in the Tsugaru Region of Aomori Prefecture, Japan. Serovar O:8 was isolated from 10 (5.2%) of 193 wild rodents trapped in June 1993 (9 of 107) and August 1993 (1 of 23) but not from animals trapped in November 1992 (0 of 63). This serovar was not isolated from 11 moles. From May to September 1993, 12 human patients were found to have become ill and to be infected with Y. enterocolitica O:8. The patients lived in the same districts where the wild rodents harboring serovar O:8 were trapped. Two different patterns by restriction enzyme analysis of the virulence plasmid were observed. One pattern obtained by restriction enzyme analysis of the virulence plasmid was observed in 20 isolates from 11 human patients and 9 wild rodents, and the other was observed in 2 isolates from 1 human patient and 1 wild rodent. These findings indicate that wild rodents seem to play an important role as a source of human Y. enterocolitica O:8 infection.