Evolution of Quorum Sensing in <i>Pseudomonas aeruginosa</i> Can Occur via Loss of Function and Regulon Modulation-Reference-Cited by-同舟云学术

Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Jayakumar Priyanikha¹^ORCID,Figueiredo Alexandre R. T.¹²³^ORCID,Kümmerli Rolf¹^ORCID

Affiliation:

1. Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland

2. Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland

3. Department of Zoology, University of Oxford, Oxford, United Kingdom

Abstract

Pseudomonas aeruginosa uses quorum sensing (QS), a three-unit multilayered network, to coordinate expression of traits required for growth and virulence in the context of infections. Despite its importance for bacterial fitness, the QS regulon appears to be a common mutational target during long-term adaptation of P. aeruginosa in the host, natural environments, and experimental evolutions.

Funder

EC | European Research Council

Swiss National Science Foundation

University Research Priority Program

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00354-22

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