System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact on Streptomyces Development

Author:

Du Chao1ORCID,Willemse Joost1,Erkelens Amanda M.1,Carrion Victor J.1,Dame Remus T.1,van Wezel Gilles P.1ORCID

Affiliation:

1. Centre for Microbial Cell Biology, Leiden University, Leiden, The Netherlands

Abstract

A large part of the chemical space of bioactive natural products is derived from Actinobacteria . Many of the biosynthetic gene clusters for these compounds are cryptic; in others words, they are expressed in nature but not in the laboratory.

Funder

Netherlands Organization for Scientific Research

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Reference91 articles.

1. Taxonomy, Physiology, and Natural Products of Actinobacteria

2. Hopwood DA. 2007. Streptomyces in nature and medicine: the antibiotic makers. Oxford University Press, Oxford, United Kingdom.

3. Bioactive Microbial Metabolites

4. Chater KF, Losick R. 1997. Mycelial life style of Streptomyces coelicolor A3(2) and its relatives, p 149–182. In Shapiro JA, Dworkin M (ed), Bacteria as multicellular organisms. Oxford University Press, New York, NY.

5. Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies

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