Genomic and Phenotypic Evolution of Achromobacter xylosoxidans during Chronic Airway Infections of Patients with Cystic Fibrosis

Author:

Khademi S. M. Hossein1ORCID,Gabrielaite Migle2ORCID,Paulsson Magnus13,Knulst Mattis1,Touriki Eleni4,Marvig Rasmus L.2,Påhlman Lisa I.135

Affiliation:

1. Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden

2. Center for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark

3. Division of Infectious Diseases, Skåne University Hospital Lund, Lund, Sweden

4. Clinical Microbiology, Labmedicin Skåne, Lund, Sweden

5. Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden

Abstract

A thorough understanding of bacterial pathogen adaptation is essential for the treatment of chronic bacterial infections. One unique challenge in the analysis and interpretation of genomics data is identifying the function impact of mutations accumulated in the bacterial genome during colonization in the human host.

Funder

MIMS Clinical Research Fellows

Danmarks Grundforskningsfond

Knut och Alice Wallenbergs Stiftelse

Kungliga Fysiografiska Sällskapet i Lund

Svenska Sällskapet för Medicinsk Forskning

Vetenskapsrådet

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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