Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome-Reference-Cited by-同舟云学术

Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Hwang Soonkyu¹²,Lee Namil¹²,Choe Donghui¹²,Lee Yongjae¹²,Kim Woori¹²,Jeong Yujin¹²,Cho Suhyung¹²,Palsson Bernhard O.³⁴⁵^ORCID,Cho Byung-Kwan¹²⁶⁷^ORCID

Affiliation:

1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

2. KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

3. Department of Bioengineering, University of California San Diego, La Jolla, California, USA

4. Department of Pediatrics, University of California San Diego, La Jolla, California, USA

5. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

6. Intelligent Synthetic Biology Center, Daejeon, South Korea

7. Innovative Biomaterials Research Center, KAIST Institutes, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

Abstract

Streptomyces sp. is a great source of bioactive secondary metabolites, including antibiotics, antifungal agents, antiparasitic agents, immunosuppressant compounds, and other drugs. Secondary metabolites are synthesized via multistep conversions of the precursor molecules from primary metabolism, governed by multicomplex enzymes from secondary metabolite biosynthetic gene clusters.

Funder

Novo Nordisk Fonden

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.01013-20

Reference65 articles.

1. Comparative Genomics Reveals the Core and Accessory Genomes of Streptomyces Species

2. Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

3. Synthetic Biology Tools for Novel Secondary Metabolite Discovery in Streptomyces

4. Towards a new science of secondary metabolism

5. Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. BacTermFinder: A Comprehensive and General Bacterial Terminator Finder using a CNN Ensemble;2024-07-08

2. Characterization of bacterial intrinsic transcription terminators identified with TERMITe – a novel method for comprehensive analysis of Term-seq data;2024-05-21

3. BATTER: Accurate Prediction of Rho-dependent and Rho-independent Transcription Terminators in Metagenomes;2023-10-03

4. Identification of RimR2 as a positive pathway-specific regulator of rimocidin biosynthesis in Streptomyces rimosus M527;Microbial Cell Factories;2023-02-21

5. Development of highly characterized genetic bioparts for efficient gene expression in CO2-fixing Eubacterium limosum;Metabolic Engineering;2022-07