Comparative Genomics and Metabolomics in the Genus Nocardia-Reference-Cited by-同舟云学术

Comparative Genomics and Metabolomics in the Genus Nocardia

Published:2020-06-30 Issue:3 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Männle Daniel¹²³^ORCID,McKinnie Shaun M. K.⁴^ORCID,Mantri Shrikant S.²³^ORCID,Steinke Katharina²³,Lu Zeyin¹²,Moore Bradley S.⁵⁶^ORCID,Ziemert Nadine²³^ORCID,Kaysser Leonard¹²^ORCID

Affiliation:

1. Pharmaceutical Biology, Eberhard Karls University Tübingen, Tübingen, Germany

2. German Centre for Infection Research (DZIF), Tübingen, Germany

3. Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), Microbiology and Biotechnology, University of Tübingen, Tübingen, Germany

4. Department of Chemistry and Biochemistry, University of California, Santa Cruz, California, USA

5. Scripps Institution of Oceanography, University of California, San Diego, California, USA

6. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, USA

Abstract

Our work emphasizes that Nocardia represent a prolific source for natural products rivaling better-characterized genera such as Streptomyces or Amycolatopsis . Furthermore, we showed that large-scale analysis of biosynthetic gene clusters using similarity networks with high stringency allows the distinction and prediction of natural product structural variations. This will facilitate future genomics-driven drug discovery campaigns.

Funder

HHS | National Institutes of Health

Deutsche Forschungsgemeinschaft

German-American Fulbright Commission

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00125-20

Reference71 articles.

1. Natural Products as Sources of New Drugs from 1981 to 2014

2. Bioactive natural products from novel microbial sources

3. Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

4. The evolution of genome mining in microbes – a review

5. Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development;mSystems;2024-09-06

2. Distribution of antibiotic resistance genes and antibiotic residues in drinking water production facilities: Links to bacterial community;PLOS ONE;2024-05-23

3. NP³ MS Workflow: An Open-Source Software System to Empower Natural Product-Based Drug Discovery Using Untargeted Metabolomics;Analytical Chemistry;2024-05-03

4. Genomic insights and anti-phytopathogenic potential of siderophore metabolome of endolithic Nocardia mangyaensis NH1;Scientific Reports;2024-03-07

5. Exploring the biosynthetic gene clusters in Brevibacterium: a comparative genomic analysis of diversity and distribution;BMC Genomics;2023-10-19