Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics-Reference-Cited by-同舟云学术

Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics

Published:2021-08-31 Issue:4 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Ernst Orna¹,Khan Mohd M.²³,Oyler Benjamin L.³,Yoon Sung Hwan²,Sun Jing¹,Lin Fang-Yu⁴,Manes Nathan P.²^ORCID,MacKerell Alexander D.⁴,Fraser Iain D. C.¹,Ernst Robert K.⁵^ORCID,Goodlett David R.⁵,Nita-Lazar Aleksandra²^ORCID

Affiliation:

1. Signaling Systems Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

2. Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

3. School of Medicine, University of Maryland, Baltimore, Maryland, USA

4. Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA

5. Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA

Abstract

Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage. This response is facilitated by specific receptors on the cell surface and intracellularly.

Funder

International Research Agenda's Program for the Foundation of Polish Science

American Association of Pharmaceutical Scientists

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Genome Canada

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00306-21

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