Systems Analysis of Gut Microbiome Influence on Metabolic Disease in HIV-Positive and High-Risk Populations

Author:

Armstrong Abigail J. S.123ORCID,Quinn Kevin4,Fouquier Jennifer1,Li Sam X.1,Schneider Jennifer M.1,Nusbacher Nichole M.1,Doenges Katrina A.4,Fiorillo Suzanne1,Marden Tyson J.5,Higgins Janine6,Reisdorph Nichole4,Campbell Thomas B.1,Palmer Brent E.1,Lozupone Catherine A.1ORCID

Affiliation:

1. Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA

2. Department of Immunology and Microbiology, University of Colorado Denver, Aurora, Colorado, USA

3. Center for Advanced Biotechnology and Medicine, Rutgers the State University, Piscataway, New Jersey, USA

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA

5. Colorado Clinical and Translational Sciences Institute, Aurora, Colorado, USA

6. Department of Pediatrics, Section of Endocrinology, University of Colorado, Aurora, Colorado, USA

Abstract

The gut microbiome in people living with HIV (PLWH) is of interest since chronic infection often results in long-term comorbidities. Metabolic disease is prevalent in PLWH even in well-controlled infection and has been linked with the gut microbiome in previous studies, but little attention has been given to PLWH.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | NIH Office of the Director

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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