Disrupting the ArcA Regulatory Network Amplifies the Fitness Cost of Tetracycline Resistance in Escherichia coli-Reference-Cited by-同舟云学术

Disrupting the ArcA Regulatory Network Amplifies the Fitness Cost of Tetracycline Resistance in Escherichia coli

Published:2023-02-23 Issue:1 Volume:8 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Arrieta-Ortiz Mario L.¹^ORCID,Pan Min¹,Kaur Amardeep¹,Pepper-Tunick Evan¹²,Srinivas Vivek¹,Dash Ananya¹,Immanuel Selva Rupa Christinal¹,Brooks Aaron N.³,Shepherd Tyson R.³,Baliga Nitin S.¹²⁴⁵⁶^ORCID

Affiliation:

1. Institute for Systems Biology, Seattle, Washington, USA

2. Molecular Engineering Sciences Institute, University of Washington, Seattle, Washington, USA

3. Inscripta Inc, Boulder, Colorado, USA

4. Department of Biology, University of Washington, Seattle, Washington, USA

5. Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, USA

6. Lawrence Berkeley National Lab, Berkeley, California, USA

Abstract

Antimicrobial resistance (AMR) is projected to be the cause of >10 million deaths annually by 2050. While efforts to find new potent antibiotics are effective, they are expensive and outpaced by the rate at which new resistant strains emerge.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00904-22

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5. The antibiotic resistance crisis: part 1: causes and threats;Ventola CL;Pharm Ther,2015

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