Comparison of Transcriptional Responses and Metabolic Alterations in Three Multidrug-Resistant Model Microorganisms, Staphylococcus aureus ATCC BAA-39, Escherichia coli ATCC BAA-196, and Acinetobacter baumannii ATCC BAA-1790, on Exposure to Iodine-Containing Nano-micelle Drug FS-1

Author:

Korotetskiy Ilya S.1ORCID,Shilov Sergey V.1,Kuznetsova Tatyana V.1,Ilin Aleksandr I.1,Joubert Monique2,Taukobong Setshaba2,Reva Oleg N.2ORCID

Affiliation:

1. Scientific Center for Anti-Infectious Drugs, Almaty, Kazakhstan

2. Centre for Bioinformatics and Computational Biology, Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa

Abstract

Infections caused by antibiotic-resistant bacteria threaten public health worldwide. Combinatorial therapy in which antibiotics are administered together with supplementary drugs improving susceptibility of pathogens to the regular antibiotics is considered a promising way to overcome this problem.

Funder

Ministry of Industry and Infrastructural Development of the Republic of Kazakhstan

National Research Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Reference51 articles.

1. Iodine in Medicine and Pharmacy since its Discovery—1811–1961

2. Further observations on penicillin. 1941;Abraham EP;Eur J Clin Pharmacol,1992

3. Mechanisms of Antibiotic Resistance

4. The impact of antibiotic use on resistance development and persistence

5. Nicolaou KC, Montagnon T. 2008. Molecules that changed the world. Wiley-VCH, Weinheim, Germany.

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