Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response-Reference-Cited by-同舟云学术

Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response

Published:2018-10-30 Issue:5 Volume:3 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Quillin Sarah J.¹,Hockenberry Adam J.²³,Jewett Michael C.⁴²³,Seifert H Steven¹^ORCID

Affiliation:

1. Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

2. Center for Synthetic Biology, Northwestern University, Evanston, Illinois, USA

3. Interdisciplinary Program in Biological Sciences, Northwestern University, Evanston, Illinois, USA

4. Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA

Abstract

The strict human pathogen Neisseria gonorrhoeae is the only causative agent of the sexually transmitted disease gonorrhea. This bacterium encounters hydrogen peroxide produced from host cells during infection, but the organism survives in the presence of this antimicrobial agent. This work shows that the bacterium responds to hydrogen peroxide by regulating the expression of many genes involved in multiple processes.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00156-18

Reference119 articles.

1. Neisseria gonorrhoeae : Colonial Morphology of Rectal Isolates

2. GonococcaI Conjunctivitis in a Four-month-oId Infant

3. Studies on the Relationships between Serum Bactericidal Activity and Uncomplicated Genital Infections Due to Neisseria gonorrhoeae

4. The Molecular Mechanisms Used by Neisseria gonorrhoeae To Initiate Infection Differ between Men and Women

5. Resistance ofNeisseria gonorrhoeaeto non-oxidative killing by adherent human polymorphonuclear leucocytes

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transcriptional responses of Neisseria gonorrhoeae to glucose and lactate: implications for resistance to oxidative damage and biofilm formation;mBio;2024-08-14

2. Dual species transcriptomics reveals conserved metabolic and immunologic processes in interactions between human neutrophils and Neisseria gonorrhoeae;PLOS Pathogens;2024-07-08

3. Shear rate sensitizes bacterial pathogens to H ₂ O ₂ stress;Proceedings of the National Academy of Sciences;2023-03-08

4. Thiostrepton, a resurging drug inhibiting the stringent response to counteract antibiotic-resistance and expression of virulence determinants in Neisseria gonorrhoeae;Frontiers in Microbiology;2023-02-23

5. The Neisseria gonorrhoeae type IV pilus promotes resistance to hydrogen peroxide- and LL-37-mediated killing by modulating the availability of intracellular, labile iron;PLOS Pathogens;2022-06-17